Our mission
We study how immune cells and molecules
interact, adapt, and change across tissues and time.
We build experimental and computational tools
to reveal and leverage those dynamics for human health.
What we study
How do immune cells organize and communicate within tissues? What causes protective responses to become damaging?
We uncover the principles that govern immune cell organization and communication in healthy and diseased tissues. By developing spatial and molecular technologies, we aim to identify the interactions that drive tissue immunity and pathology in settings such as lung fibrosis and other chronic diseases.
Which immune trajectories preserve resilience, and which lead to dysfunction?
We develop experimental and computational approaches to measure immune change across development, aging, and chronic disease. Our goal is to reveal the trajectories that shape immune resilience, dysfunction, and variation between individuals.
How are adaptive immune responses generated, refined, remembered, and redirected?
We investigate how B and T cell responses evolve across space and time, from antigen recognition and affinity maturation to immune memory. By connecting immune repertoires with tissue context and function, we aim to understand what makes immunity durable, specific, and protective in infectious disease and cancer.