Research Areas
Understanding our immune systems is critical to improving human health. We engineer tools to ask new biological questions, in particular for characterizing spatial and temporal dynamics of cells in tissues.
Immune Cell Interactions in Tissues
How do immune cell interactions affect tissue structure and state?
The intricate dynamics of immune cell interactions within various tissues profoundly impact tissue structure and state. We are dedicated to unraveling the complexities of the immune system's behavior and its critical role in maintaining tissue homeostasis and responding to pathological challenges. By investigating healthy and disease states, we aim to shed light on the processes leading to immune-mediated tissue damage and identify potential therapeutic targets.
Dynamics Across Immune Development and Aging
Can we build tools to study how the immune system changes over long time scales?
We investigate the dynamic changes that occur in the immune system across different stages of life, encompassing both immune development and aging. We aim to develop innovative computational and experimental tools and methodologies that enable the study of long time scales in immunology and the prediction of immune trends.
T and B Cell Repertoires
How can we study adaptive immunity in situ to improve the immune response?
We are interested in the diversity and functionality of T and B cell repertoires in the tissue context. Understanding the dynamic nature of these repertoires is crucial for enhancing the immune response and developing targeted therapeutic interventions. Our investigations center around studying adaptive immunity in situ, in particular antigen recognition and response, to decipher the complex interactions between immune cells and antigens within their native tissue microenvironments.